human PCDHA4 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human PCDHA4.
shADV-230352
Ad-h-PCDHA4-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human PCDHA4 (protocadherin alpha 4). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CNR1; CNRN1; CRNR1; PCDH-ALPHA4
Description (Vector)
PCDHA4 is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.
Gene ID
56144
Gene Name (Vector)
protocadherin alpha 4
Gene Symbol
PCDHA4
HGNC ID
HGNC:8670
ORF Size (aa)
2397
ORF Size (bp)
2397 bp
RefSeq ID
NM_018907
RefSeq Synonyms
NM_031500, NM_018907, BC113609, BC112102,
Species
human
UniGene ID
Hs.
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.