human PCDHGB1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human PCDHGB1.
shADV-229885
Ad-h-PCDHGB1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human PCDHGB1 (protocadherin gamma subfamily B, 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
PCDH-GAMMA-B1
Description (Vector)
PCDHGB1 is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.
Gene ID
56104
Gene Name (Vector)
protocadherin gamma subfamily B, 1
Gene Symbol
PCDHGB1
HGNC ID
HGNC:8708
ORF Size (aa)
2433
ORF Size (bp)
2433 bp
RefSeq ID
NM_018922
RefSeq Synonyms
NM_032095, NM_018922, BC103928, BC103927, BC103926,
Species
human
UniGene ID
Hs.
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.