human WDR12 shRNA silencing Adenovirus

Name 
Ad-h-WDR12-shRNA
Cat No 
shADV-227641
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human WDR12.

shADV-227641
Ad-h-WDR12-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human WDR12 (WD repeat domain 12). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
ribosome biogenesis protein WDR12; WD repeat-containing protein 12; YTM1
Description (eCommerce)
WDR12 is a component of the PeBoW complex. PeBoW is required for the maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9GZL7].
Description (Vector)
WDR12 encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein is highly similar to the mouse WD repeat domain 12 protein at the amino acid level. The protein encoded by this gene is a component of a nucleolar protein complex that affects maturation of the large ribosomal subunit.
Gene ID
55759
Gene Name (eCommerce)
WD repeat domain 12
Gene Name (Vector)
WD repeat domain 12
Gene Symbol
WDR12
HGNC ID
HGNC:14098
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1272
Protein Name (eCommerce)
Ribosome biogenesis protein WDR12
RefSeq ID
NM_018256
RefSeq Synonyms
NM_018256, BC008082,
Research Areas
Notch Signaling,RNA Processing,Signal Transduction
Research Areas (Faceted)
cell_biology,developmental_biology,genetics,signal_transduction,transcription_translation
Species
human
Target Sentence
WDR12 is a component of the PeBoW complex. PeBoW is required for the maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9GZL7].
UniGene ID
Hs.73291
UniProt ID (eCommerce)
Q9GZL7

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.