human VPS26A shRNA silencing Adenovirus

Name 
Ad-h-VPS26A-shRNA
Cat No 
shADV-227517
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human VPS26A.

shADV-227517
Ad-h-VPS26A-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human VPS26A (VPS26, retromer complex component A). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
89
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
HB58; Hbeta58; hVPS26; PEP8A; vacuolar protein sorting 26 homolog A; vacuolar protein sorting-associated protein 26A; vesicle protein sorting 26A; VPS26; VPS26 retromer complex comonent A
Description (eCommerce)
VPS26A belongs to a group of vacuolar protein sorting (VPS) genes. VPS26A is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex [taken from NCBI Entrez Gene (Gene ID: 9559)].
Description (Vector)
VPS26A belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. Alternative splicing results in multiple transcript variants encoding different isoforms.
Gene ID
9559
Gene Name (eCommerce)
VPS26, retromer complex component A
Gene Name (Vector)
VPS26, retromer complex component A
Gene Symbol
VPS26A
HGNC ID
HGNC:12711
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
984
Protein Name (eCommerce)
Vacuolar protein sorting-associated protein 26A
RefSeq ID
NM_004896
RefSeq Synonyms
NM_004896, NM_001318946, NM_001318945, NM_001318944, NM_001035260, BC022505,
Research Areas
Golgi Apparatus,Signal Transduction,Wnt Signaling
Research Areas (Faceted)
cell_biology,signal_transduction
Species
human
Target Sentence
VPS26A belongs to a group of vacuolar protein sorting (VPS) genes. VPS26A is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex [taken from NCBI Entrez Gene (Gene ID: 9559)].
UniGene ID
Hs.499925
UniProt ID (eCommerce)
O75436

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.