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human VPS11 shRNA silencing Adenovirus

Name 
Ad-h-VPS11-shRNA
Cat No 
shADV-227513
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human VPS11.

shADV-227513
Ad-h-VPS11-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human VPS11 (VPS11, CORVET/HOPS core subunit). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
END1; HLD12; hVPS11; PEP5; RING finger protein 108; RNF108; vacuolar protein sorting 11 homolog; vacuolar protein sorting-associated protein 11 homolog
Description (eCommerce)
Vacuolar protein sorting 11 homolog (VPS11) may play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9H270].
Description (Vector)
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps11 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway.
Gene ID
55823
Gene Name (eCommerce)
VPS11, CORVET/HOPS core subunit
Gene Name (Vector)
VPS11, CORVET/HOPS core subunit
Gene Symbol
VPS11
HGNC ID
HGNC:14583
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2826
ORF Size (bp)
2826 bp
Protein Name (eCommerce)
Vacuolar protein sorting-associated protein 11 homolog
RefSeq ID
NM_021729
RefSeq Synonyms
NM_021729, NM_001290185, BC065563, BC012051,
Research Areas
Lysosome,Transport,Zinc-finger
Research Areas (Faceted)
cell_biology
Species
human
Target Sentence
Vacuolar protein sorting 11 homolog (VPS11) may play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9H270].
UniGene ID
Hs.234282
UniProt ID (eCommerce)
Q9H270

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.