human VARS shRNA silencing Adenovirus

Name
Ad-h-VARS-shRNA

Cat No
shADV-227395

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Human VARS.

shADV-227395

Ad-h-VARS-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human VARS (valyl-tRNA synthetase). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

80

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

G7A; NDMSCA; protein G7a; valine tRNA ligase 1, cytoplasmic; valine--tRNA ligase; valRS; Valyl-tRNA synthetase; valyl-tRNA synthetase 2; VARS1; VARS2

Description (eCommerce)

Valyl-tRNA Synthetase / VARS is an aminoacyl-tRNA synthetase. It catalyzes the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolutio [taken from NCBI Entrez Gene (Gene ID: 7407)].

Description (Vector)

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. The protein encoded by this gene belongs to class-I aminoacyl-tRNA synthetase family and is located in the class III region of the major histocompatibility complex.

Gene ID

7407

Gene Name (eCommerce)

valyl-tRNA synthetase

Gene Name (Vector)

valyl-tRNA synthetase

Gene Symbol

VARS

HGNC ID

HGNC:12651

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

3795

ORF Size (bp)

3795 bp

Protein Name (eCommerce)

Valine--tRNA ligase

RefSeq ID

NM_006295

RefSeq Synonyms

NM_006295, BC012808,

Research Areas

Gene Expression,Mitochondrion,Translational Control

Research Areas (Faceted)

cell_biology,transcription_translation

Species

human

Target Sentence

Valyl-tRNA Synthetase / VARS is an aminoacyl-tRNA synthetase. It catalyzes the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolutio [taken from NCBI Entrez Gene (Gene ID: 7407)].

UniGene ID

Hs.520026

UniProt ID (eCommerce)

P26640

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.