human USP39 shRNA silencing Adenovirus

Name
Ad-h-USP39-shRNA

Cat No
shADV-227319

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Human USP39.

shADV-227319

Ad-h-USP39-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human USP39 (ubiquitin specific peptidase 39). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

90

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

65K; CGI-21; HSPC332; inactive ubiquitin-specific peptidase 39; SAD1; SAD1 homolog; small nuclear ribonucleoprotein 65kDa (U4/U6.U5); SnRNP assembly defective 1 homolog; SNRNP65; U4/U6.U5 tri-snRNP-associated 65 kDa protein; U4/U6.U5 tri-snRNP-associated protein 2; ubiquitin specific protease 39

Description (eCommerce)

USP39 plays a role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. USP39 regulates AURKB mRNA levels, and thereby plays a role in cytokinesis and in the spindle checkpoint. USP39 does not have ubiquitin-specific peptidase activity, but could be a competitor of ubiquitin C-terminal hydrolases (UCHs)Â [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q53GS9].

Gene ID

10713

Gene Name (eCommerce)

ubiquitin specific peptidase 39

Gene Name (Vector)

ubiquitin specific peptidase 39

Gene Symbol

USP39

HGNC ID

HGNC:20071

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

1698

ORF Size (bp)

1698 bp

Protein Name (eCommerce)

U4/U6.U5 tri-snRNP-associated protein 2

RefSeq ID

NM_006590

RefSeq Synonyms

NM_006590, NM_001256728, NM_001256727, NM_001256726, NM_001256725, BC067273,

Research Areas

Cell Cycle,Cell Division,Gene Expression,mRNA Processing,mRNA Splicing,RNA Processing,Spliceosome,Zinc-finger

Research Areas (Faceted)

cell_biology,cell_cycle,genetics,transcription_translation

Species

human

Target Sentence

USP39 plays a role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. USP39 regulates AURKB mRNA levels, and thereby plays a role in cytokinesis and in the spindle checkpoint. USP39 does not have ubiquitin-specific peptidase activity, but could be a competitor of ubiquitin C-terminal hydrolases (UCHs)Â [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q53GS9].

UniGene ID

Hs.654745

UniProt ID (eCommerce)

Q53GS9

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.