human UCHL1 shRNA silencing Adenovirus

Name 
Ad-h-UCHL1-shRNA
Cat No 
shADV-227099
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human UCHL1.

shADV-227099
Ad-h-UCHL1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human UCHL1 (ubiquitin C-terminal hydrolase L1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
epididymis luminal protein 117; epididymis secretory protein Li 53; HEL-117; HEL-S-53; NDGOA; neuron cytoplasmic protein 9.5; PARK5; PGP 9.5; PGP9.5; PGP95; SPG79; ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase); ubiquitin carboxyl-terminal hydrolase isozyme L1; ubiquitin thioesterase L1; ubiquitin thiolesterase; Uch-L1
Description (eCommerce)
Ubiquitin carboxyl-terminal hydrolase isozyme L1, or UCHL1, is a ubiquitin-protein hydrolase belonging to the peptidase C12 family. It hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. UCHL1 is specifically expressed in neurons and in cells of the diffuse neuroendocrine system. [taken from NCBI Entrez Gene (Gene ID: 7345)].
Description (Vector)
UCHL1 belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.
Gene ID
7345
Gene Name (eCommerce)
ubiquitin C-terminal hydrolase L1
Gene Name (Vector)
ubiquitin C-terminal hydrolase L1
Gene Symbol
UCHL1
HGNC ID
HGNC:12513
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
672
Protein Name (eCommerce)
Ubiquitin carboxyl-terminal hydrolase isozyme L1
RefSeq ID
NM_004181
RefSeq Synonyms
NM_004181, BC006305, BC005117, BC000332,
Research Areas
Apoptosis,Complexome,Neurobiology,Neurodegeneration,Parkinson's Disease,Proteasome
Research Areas (Faceted)
cell_biology,neurobiology
Species
human
Target Sentence
Ubiquitin carboxyl-terminal hydrolase isozyme L1, or UCHL1, is a ubiquitin-protein hydrolase belonging to the peptidase C12 family. It hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. UCHL1 is specifically expressed in neurons and in cells of the diffuse neuroendocrine system. [taken from NCBI Entrez Gene (Gene ID: 7345)].
UniGene ID
Hs.518731
UniProt ID (eCommerce)
P09936

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.