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human UBR1 shRNA silencing Adenovirus

Name 
Ad-h-UBR1-shRNA
Cat No 
shADV-227077
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human UBR1.

shADV-227077
Ad-h-UBR1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human UBR1 (ubiquitin protein ligase E3 component n-recognin 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
58
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
E3 ubiquitin-protein ligase UBR1; E3a ligase; JBS; N-recognin-1; RING-type E3 ubiquitin transferase UBR1; ubiquitin ligase E3 alpha-I; ubiquitin-protein ligase E3-alpha; ubiquitin-protein ligase E3-alpha-1; ubiquitin-protein ligase E3-alpha-I
Description (eCommerce)
UBR1 is an E3 ubiquitin-protein ligase that is a component of the N-end rule pathway. UBR1 recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. UBR1 may be involved in pancreatic homeostasis. UBR1 binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q8IWV7].
Description (Vector)
The N-end rule pathway is one proteolytic pathway of the ubiquitin system. The recognition component of this pathway, encoded by this gene, binds to a destabilizing N-terminal residue of a substrate protein and participates in the formation of a substrate-linked multiubiquitin chain. This leads to the eventual degradation of the substrate protein. The protein described in this record has a RING-type zinc finger and a UBR-type zinc finger. Mutations in this gene have been associated with Johanson-Blizzard syndrome.
Gene ID
197131
Gene Name (eCommerce)
ubiquitin protein ligase E3 component n-recognin 1
Gene Name (Vector)
ubiquitin protein ligase E3 component n-recognin 1
Gene Symbol
UBR1
HGNC ID
HGNC:16808
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
5250
ORF Size (bp)
5250 bp
Protein Name (eCommerce)
E3 ubiquitin-protein ligase UBR1
RefSeq ID
NM_174916
RefSeq Synonyms
NM_174916, BC113507, BC113505,
Research Areas
Antigen Processing and Presentation,Complexome,Immunology,Proteasome,Ubiquitination,Zinc-finger
Research Areas (Faceted)
cell_biology,immunology
Species
human
Target Sentence
UBR1 is an E3 ubiquitin-protein ligase that is a component of the N-end rule pathway. UBR1 recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. UBR1 may be involved in pancreatic homeostasis. UBR1 binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q8IWV7].
UniGene ID
Hs.591121
UniProt ID (eCommerce)
Q8IWV7

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.