human UBE2K shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human UBE2K.
shADV-227020
Ad-h-UBE2K-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human UBE2K (ubiquitin conjugating enzyme E2 K). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
E2 ubiquitin-conjugating enzyme K; E2(25K); E2-25K; HIP2; HIP-2; huntingtin-interacting protein 2; HYPG; LIG; UBC1; ubiquitin carrier protein; ubiquitin conjugating enzyme E2K; ubiquitin-conjugating enzyme E2 K; ubiquitin-conjugating enzyme E2(25K); ubiquitin-conjugating enzyme E2-25 KDA; Ubiquitin-conjugating enzyme E2-25K; ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast); ubiquitin-protein ligase
Description (eCommerce)
Ubiquitin-conjugating enzyme E2-25 kDa (E2-25K) belongs to the ubiquitin-conjugating enzyme family. E2-25K interacts with RING finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington's disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation [taken from NCBI Entrez Gene (Gene ID: 3093)].
Description (Vector)
UBE2K belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RING finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington's disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation. Multiple transcript variants encoding different isoforms have been identified for this gene.
Gene ID
3093
Gene Name (eCommerce)
ubiquitin conjugating enzyme E2 K
Gene Name (Vector)
ubiquitin conjugating enzyme E2 K
Gene Symbol
UBE2K
HGNC ID
HGNC:4914
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
603
Protein Name (eCommerce)
Ubiquitin-conjugating enzyme E2 K
RefSeq ID
NM_005339
RefSeq Synonyms
NM_005339, NM_001312648, NM_001312647, NM_001312646, NM_001111113, NM_001111112, BC050600, BC022804,
Research Areas
Antigen Processing and Presentation,Immunology,Ubiquitination
Research Areas (Faceted)
cell_biology,immunology
Species
human
Target Sentence
Ubiquitin-conjugating enzyme E2-25 kDa (E2-25K) belongs to the ubiquitin-conjugating enzyme family. E2-25K interacts with RING finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington's disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation [taken from NCBI Entrez Gene (Gene ID: 3093)].
UniGene ID
Hs.714332
UniProt ID (eCommerce)
P61086
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.