human TTR shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human TTR.
shADV-226757
Ad-h-TTR-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human TTR (transthyretin). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CTS; CTS1; HEL111; HsT2651; PALB; TBPA
Description (Vector)
TTR encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc.
Gene ID
7276
Gene Name (Vector)
transthyretin
Gene Symbol
TTR
HGNC ID
HGNC:12405
ORF Size (aa)
444
RefSeq ID
NM_000371
RefSeq Synonyms
NM_000371, BC020791, BC005310,
Species
human
UniGene ID
Hs.427202
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.