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human TTLL5 shRNA silencing Adenovirus

Name 
Ad-h-TTLL5-shRNA
Cat No 
shADV-226748
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human TTLL5.

shADV-226748
Ad-h-TTLL5-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human TTLL5 (tubulin tyrosine ligase like 5). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
CORD19; KIAA0998; SRC1 and TIF2 associated binding protein; SRC1 and TIF2-associated modulatory protein; STAMP; tubulin polyglutamylase TTLL5; tubulin tyrosine ligase-like family, member 5; Tubulin--tyrosine ligase-like protein 5
Description (eCommerce)
SRC1 and TIF2 associated binding protein (STAMP) is a polyglutamylase which preferentially modifies alpha-tubulin. STAMP is involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step (By similarity). It is required for CCSAP localization to both spindle and cilia microtubules. STAMP increases the effects of NCOA2 in glucocorticoid receptor-mediated repression and induction and in androgen receptor-mediated induction [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q6EMB2].
Description (Vector)
TTLL5 encodes a member of the tubulin tyrosine ligase like protein family. This protein interacts with two glucocorticoid receptor coactivators, transcriptional intermediary factor 2 and steroid receptor coactivator 1. This protein may function as a coregulator of glucocorticoid receptor mediated gene induction and repression. This protein may also function as an alpha tubulin polyglutamylase.
Gene ID
23093
Gene Name (eCommerce)
tubulin tyrosine ligase like 5
Gene Name (Vector)
tubulin tyrosine ligase like 5
Gene Symbol
TTLL5
HGNC ID
HGNC:19963
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3846
ORF Size (bp)
3846 bp
Protein Name (eCommerce)
Tubulin polyglutamylase TTLL5
RefSeq ID
NM_015072
RefSeq Synonyms
NM_015072, BC136473, BC136472, BC002766,
Research Areas
Cytoskeleton,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,transcription_translation
Species
human
Target Sentence
SRC1 and TIF2 associated binding protein (STAMP) is a polyglutamylase which preferentially modifies alpha-tubulin. STAMP is involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step (By similarity). It is required for CCSAP localization to both spindle and cilia microtubules. STAMP increases the effects of NCOA2 in glucocorticoid receptor-mediated repression and induction and in androgen receptor-mediated induction [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q6EMB2].
UniGene ID
Hs.709609
UniProt ID (eCommerce)
Q6EMB2

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.