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human TTK shRNA silencing Adenovirus

Name 
Ad-h-TTK-shRNA
Cat No 
shADV-226736
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human TTK.

shADV-226736
Ad-h-TTK-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human TTK (TTK protein kinase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
cancer/testis antigen 96; CT96; dual specificity protein kinase TTK; ESK; monopolar spindle 1 kinase; monopolar spindle 1-like 1; MPH1; MPS1; MPS1L1; phosphotyrosine picked threonine kinase; phosphotyrosine picked threonine-protein kinase; PYT
Description (eCommerce)
TTK is a cell-cycle regulated dual-specificity kinase that is part of the Mps1 family of kinases. TTK has been shown to interact with Chk2, a cell cycle checkpoint kinase, to mediate cellular responses to DNA damage. TTK has also been shown to be localized from the kinetochore to the centrosome at the entrance of anaphase, and required for mitotic spindle maintenance through the interaction with TACC2.
Description (Vector)
TTK encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants.
Gene ID
7272
Gene Name (eCommerce)
TTK protein kinase
Gene Name (Vector)
TTK protein kinase
Gene Symbol
TTK
HGNC ID
HGNC:12401
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2574
ORF Size (bp)
2574 bp
Protein Name (eCommerce)
Dual specificity protein kinase TTK
RefSeq ID
NM_003318
RefSeq Synonyms
NM_003318, NM_001166691, BC032858, BC000633,
Research Areas
Cell Cycle,Cell Division,Immunology,Kinase/Phosphatase
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,immunology,signal_transduction
Species
human
Target Sentence
TTK is a cell-cycle regulated dual-specificity kinase that is part of the Mps1 family of kinases. TTK has been shown to interact with Chk2, a cell cycle checkpoint kinase, to mediate cellular responses to DNA damage. TTK has also been shown to be localized from the kinetochore to the centrosome at the entrance of anaphase, and required for mitotic spindle maintenance through the interaction with TACC2.
UniGene ID
Hs.169840
UniProt ID (eCommerce)
P33981

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.