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human TSPYL2 shRNA silencing Adenovirus

Name 
Ad-h-TSPYL2-shRNA
Cat No 
shADV-226659
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human TSPYL2.

shADV-226659
Ad-h-TSPYL2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human TSPYL2 (TSPY like 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
CASK-interacting nucleosome assembly protein; CDA1; cell division autoantigen 1; CINAP; CTCL; CTCL tumor antigen se20-4; CTCL-associated antigen se20-4; cutaneous T-cell lymphoma-associated antigen se20-4; cutaneous T-cell lymphoma-associated tumor antigen se20-4; DENTT; differentially expressed nucleolar TGF-beta1 target; differentially-expressed nucleolar TGF-beta1 target protein; HRIHFB2216; NP79; nuclear protein of 79 kDa; SE204; testis-specific protein Y encoded-like 2; testis-specific Y-encoded-like protein 2; TSPX; TSPY-like protein 2
Description (eCommerce)
Differentially-expressed nucleolar TGF-beta1 target protein (DENTT) is part of the CASK/TRB1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. DENTT may inhibit cell proliferation by inducing p53-dependent CDKN1A expression [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9H2G4].
Description (Vector)
TSPYL2 encodes a member of the testis-specific protein Y-encoded, TSPY-like/SET/nucleosome assembly protein-1 superfamily. The encoded protein is localized to the nucleolus where it functions in chromatin remodeling and as an inhibitor of cell-cycle progression. This protein may play a role in the suppression of tumor growth.
Gene ID
64061
Gene Name (eCommerce)
TSPY like 2
Gene Name (Vector)
TSPY like 2
Gene Symbol
TSPYL2
HGNC ID
HGNC:24358
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2082
ORF Size (bp)
2082 bp
Protein Name (eCommerce)
Testis-specific Y-encoded-like protein 2
RefSeq ID
NM_022117
RefSeq Synonyms
NM_022117, BC024270,
Research Areas
Cell Cycle,Chromatin Remodeling,DNA Replication,Replication,Signal Transduction,Transcription Factor/Regulator
Research Areas (Faceted)
signal_transduction,cell_biology,cell_cycle,genetics,transcription_translation
Species
human
Target Sentence
Differentially-expressed nucleolar TGF-beta1 target protein (DENTT) is part of the CASK/TRB1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. DENTT may inhibit cell proliferation by inducing p53-dependent CDKN1A expression [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9H2G4].
UniGene ID
Hs.136164
UniProt ID (eCommerce)
Q9H2G4

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.