human TSEPA shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human THEMIS.
shADV-226595
Ad-h-TSEPA-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human THEMIS (thymocyte selection associated). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
C6orf190; C6orf207; GASP; GRB2-associated protein; protein THEMIS; signaling phosphoprotein specific for T cells; SPOT; thymocyte selection pathway associated; thymocyte-expressed molecule involved in selection; TSEPA
Description (eCommerce)
Thymocyte-expressed molecule involved in selection (THEMIS) plays a regulatory role in both positive and negative T-cell selection during late thymocyte development. The protein functions through T-cell antigen receptor signaling, and is necessary for proper lineage commitment and maturation of T-cells [taken from NCBI Entrez Gene (Gene ID: 387357)].
Description (Vector)
THEMIS encodes a protein that plays a regulatory role in both positive and negative T-cell selection during late thymocyte development. The protein functions through T-cell antigen receptor signaling, and is necessary for proper lineage commitment and maturation of T-cells. Alternative splicing results in multiple transcript variants.
Gene ID
387357
Gene Name (eCommerce)
thymocyte selection associated
Gene Name (Vector)
thymocyte selection associated
Gene Symbol
THEMIS
HGNC ID
HGNC:21569
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1926
ORF Size (bp)
1926 bp
Protein Name (eCommerce)
Protein THEMIS
RefSeq ID
NM_001318531
RefSeq Synonyms
NM_001318531, NM_001164687, NM_001164685, NM_001010923, BC130516,
Research Areas
Immunology,T-cell Receptor Signaling
Research Areas (Faceted)
signal_transduction,immunology
Species
human
Target Sentence
Thymocyte-expressed molecule involved in selection (THEMIS) plays a regulatory role in both positive and negative T-cell selection during late thymocyte development. The protein functions through T-cell antigen receptor signaling, and is necessary for proper lineage commitment and maturation of T-cells [taken from NCBI Entrez Gene (Gene ID: 387357)].
UniGene ID
Hs.661756
UniProt ID (eCommerce)
Q8N1K5
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.