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human TRIM37 shRNA silencing Adenovirus

Name 
Ad-h-TRIM37-shRNA
Cat No 
shADV-226428
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human TRIM37.

shADV-226428
Ad-h-TRIM37-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human TRIM37 (tripartite motif containing 37). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
70
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
E3 ubiquitin-protein ligase TRIM37; MUL; mulibrey nanism protein; POB1; RING-B-box-coiled-coil protein; RING-type E3 ubiquitin transferase TRIM37; TEF3; Tripartite motif-containing protein 37
Description (eCommerce)
TRIM37 is a member of the tripartite motif RBCC/Trim domain family that contains a RING-finger domain, B-boxes, and an alpha-helical coiled-coil region. TRIM37 is a peroxisomal protein whose function has not been determined. Mutations in TRIM37 result in mulibrey (MUscle, LIver, BRain, and EYes) nanism (‘dwarfism’), a rare autosomal recessive disorder characterized by defects in tissues of mesodermal origin.
Description (Vector)
TRIM37 encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might be involved in protein-protein and/or protein-nucleic acid interactions. The gene mutations are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder that involves several tissues of mesodermal origin. Alternatively spliced transcript variants encoding the same protein have been identified.
Gene ID
4591
Gene Name (eCommerce)
tripartite motif containing 37
Gene Name (Vector)
tripartite motif containing 37
Gene Symbol
TRIM37
HGNC ID
HGNC:7523
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2895
ORF Size (bp)
2895 bp
Protein Name (eCommerce)
E3 ubiquitin-protein ligase TRIM37
RefSeq ID
NM_015294
RefSeq Synonyms
NM_015294, NM_001320990, NM_001320989, NM_001320988, NM_001320987, NM_001005207, BC036012,
Research Areas
Antigen Processing and Presentation,Cancer,Immunology,Tumor Suppressors/Oncoproteins,Ubiquitination,Zinc-finger
Research Areas (Faceted)
cancer,cell_biology,immunology
Species
human
Target Sentence
TRIM37 is a member of the tripartite motif RBCC/Trim domain family that contains a RING-finger domain, B-boxes, and an alpha-helical coiled-coil region. TRIM37 is a peroxisomal protein whose function has not been determined. Mutations in TRIM37 result in mulibrey (MUscle, LIver, BRain, and EYes) nanism (‘dwarfism’), a rare autosomal recessive disorder characterized by defects in tissues of mesodermal origin.
UniGene ID
Hs.605697
UniProt ID (eCommerce)
O94972

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.