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human TRIM3 shRNA silencing Adenovirus

Name 
Ad-h-TRIM3-shRNA
Cat No 
shADV-226423
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human TRIM3.

shADV-226423
Ad-h-TRIM3-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human TRIM3 (tripartite motif containing 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
BERP; brain expressed ring finger; brain-expressed RING finger protein; HAC1; ring finger protein 22; RING finger protein 97; RNF22; RNF97; tripartite motif protein TRIM3; tripartite motif-containing protein 3
Description (eCommerce)
TRIM3/BERP is a member of the tripartite motif RBCC/Trim domain family that contains a RING-finger domain, B-boxes, and an alpha-helical coiled-coil region. TRIM3/BERP has been identified as a component of the CART (cytoskeleton-associated recycling or transport) complex which includes actinin-4, hrs, myosin V, and TRIM3/BERP. In this complex TRIM/BERP is involved in the recycling of plasma membrane receptors.
Description (Vector)
TRIM3 is a member of the tripartite motif (TRIM) family, also called the 'RING-B-box-coiled-coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic filaments. It is similar to a rat protein which is a specific partner for the tail domain of myosin V, a class of myosins which are involved in the targeted transport of organelles. The rat protein can also interact with alpha-actinin-4. Thus it is suggested that this human protein may play a role in myosin V-mediated cargo transport. Alternatively spliced transcript variants encoding the same isoform have been identified.
Gene ID
10612
Gene Name (eCommerce)
tripartite motif containing 3
Gene Name (Vector)
tripartite motif containing 3
Gene Symbol
TRIM3
HGNC ID
HGNC:10064
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2235
ORF Size (bp)
2235 bp
Protein Name (eCommerce)
Tripartite motif-containing protein 3
RefSeq ID
NM_006458
RefSeq Synonyms
NM_033278, NM_006458, NM_001248007, NM_001248006, BC096827,
Research Areas
DNA Damage/Repair,Neurobiology,Neurodevelopment,Zinc-finger
Research Areas (Faceted)
genetics,transcription_translation,neurobiology,developmental_biology,cell_biology
Species
human
Target Sentence
TRIM3/BERP is a member of the tripartite motif RBCC/Trim domain family that contains a RING-finger domain, B-boxes, and an alpha-helical coiled-coil region. TRIM3/BERP has been identified as a component of the CART (cytoskeleton-associated recycling or transport) complex which includes actinin-4, hrs, myosin V, and TRIM3/BERP. In this complex TRIM/BERP is involved in the recycling of plasma membrane receptors.
UniGene ID
Hs.591992
UniProt ID (eCommerce)
O75382

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.