human TRIB2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human TRIB2.
shADV-226392
Ad-h-TRIB2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human TRIB2 (tribbles pseudokinase 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
C5FW; GS3955; TRB2
Description (Vector)
TRIB2 encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene.
Gene ID
28951
Gene Name (Vector)
tribbles pseudokinase 2
Gene Symbol
TRIB2
HGNC ID
HGNC:30809
ORF Size (aa)
1032
RefSeq ID
NM_021643
RefSeq Synonyms
NM_021643, BC002637,
Species
human
UniGene ID
Hs.467751
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.