human TPM1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human TPM1.
shADV-226269
Ad-h-TPM1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human TPM1 (tropomyosin 1 (alpha)). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
C15orf13; CMD1Y; CMH3; HEL-S-265; HTM-alpha; LVNC9; TMSA
Description (Vector)
TPM1 is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy.
Gene ID
7168
Gene Name (Vector)
tropomyosin 1 (alpha)
Gene Symbol
TPM1
HGNC ID
HGNC:12010
ORF Size (aa)
738
RefSeq ID
NM_000366
RefSeq Synonyms
NM_001330351, NM_001330346, NM_001330344, NM_001301289, NM_001301244, NM_001018020, NM_001018008, NM_001018007, NM_001018006, NM_001018005, NM_001018004, NM_000366, BC053545, BC007433,
Species
human
UniGene ID
Hs.133892
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.