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human TP73 shRNA silencing Adenovirus

Name 
Ad-h-TP73-shRNA
Cat No 
shADV-226241
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human TP73.

shADV-226241
Ad-h-TP73-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human TP73 (tumor protein p73). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
p53-like transcription factor; p53-related protein; P73; tumor protein p73
Description (eCommerce)
p73 is a p53-related protein and a member of the family of transcription factors which include p53, p63 and p73. Although structurally and functionally related, it appears that the members of this family possess their own unique functions. No human genetic disorders have been linked to germ line mutations of p73; however, loss of heterozygosity has been associated with some cancers although the incidence is rare. Generally speaking, p73 appears to play an important role in gene transactivation and growth suppression. P73 participates in the apoptotic response to DNA damage and may function in connection with p53.
Description (Vector)
TP73 encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined.
Gene ID
7161
Gene Name (eCommerce)
tumor protein p73
Gene Name (Vector)
tumor protein p73
Gene Symbol
TP73
HGNC ID
HGNC:12003
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1911
ORF Size (bp)
1911 bp
Protein Name (eCommerce)
Tumor protein p73
RefSeq ID
NM_005427
RefSeq Synonyms
NM_005427, NM_001204192, NM_001204191, NM_001204190, NM_001204189, NM_001204188, NM_001204187, NM_001204186, NM_001204185, NM_001204184, NM_001126242, NM_001126241, NM_001126240, BC117253, BC117251,
Research Areas
Apoptosis,Cancer,Cell Cycle,DNA Damage/Repair,Hippo Signaling,Host-Virus Interactions,Immunology,JNK Signaling,Neurobiology,Neurodevelopment,p53 Signaling,Signal Transduction,TGF-beta Signaling,Transcription Factor/Regulator,Tumor Suppressors/Oncoproteins
Research Areas (Faceted)
cancer,signal_transduction,cell_biology,cell_cycle,genetics,transcription_translation,signal_transduction,developmental_biology,infectious_disease,immunology,signal_transduction,neurobiology,developmental_biology,signal_transduction,immunology,genetics,transcription_translation,cancer
Species
human
Target Sentence
p73 is a p53-related protein and a member of the family of transcription factors which include p53, p63 and p73. Although structurally and functionally related, it appears that the members of this family possess their own unique functions. No human genetic disorders have been linked to germ line mutations of p73; however, loss of heterozygosity has been associated with some cancers although the incidence is rare. Generally speaking, p73 appears to play an important role in gene transactivation and growth suppression. P73 participates in the apoptotic response to DNA damage and may function in connection with p53.
UniGene ID
Hs.697294
UniProt ID (eCommerce)
O15350

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.