human TIMP2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human TIMP2.
shADV-225531
Ad-h-TIMP2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human TIMP2 (TIMP metallopeptidase inhibitor 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CSC-21K; DDC8
Description (Vector)
TIMP2 is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix.
Gene ID
7077
Gene Name (Vector)
TIMP metallopeptidase inhibitor 2
Gene Symbol
TIMP2
HGNC ID
HGNC:11821
ORF Size (aa)
663
RefSeq ID
NM_003255
RefSeq Synonyms
NM_003255, BC071586, BC052605,
Species
human
UniGene ID
Hs.633514
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.