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human TCF12 shRNA silencing Adenovirus

Name 
Ad-h-TCF12-shRNA
Cat No 
shADV-225204
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human TCF12.

shADV-225204
Ad-h-TCF12-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human TCF12 (transcription factor 12). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
bHLHb20; class B basic helix-loop-helix protein 20; CRS3; DNA-binding protein HTF4; E-box-binding protein; HEB; helix-loop-helix transcription factor 4; HsT17266; HTF4; p64; TCF-12; transcription factor 12; transcription factor HTF-4
Description (eCommerce)
TCF12 (transcription factor 12), also known as HeLa E-box binding protein (HEB), is basic helix-loop-helix (bHLH) transcription factor that recognizes consensus E-box binding sites and is found to be important for T-cell development and cell differentiation. TCF12 can interact with the immunoglobulin enhancer binding proteins E12 and ITF2 as hetero-oligomers to modulate their DNA binding activity.
Description (Vector)
TCF12 is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. This encoded protein is expressed in many tissues, among them skeletal muscle, thymus, B- and T-cells, and may participate in regulating lineage-specific gene expression through the formation of heterodimers with other bHLH E-proteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
Gene ID
6938
Gene Name (eCommerce)
transcription factor 12
Gene Name (Vector)
transcription factor 12
Gene Symbol
TCF12
HGNC ID
HGNC:11623
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2121
ORF Size (bp)
2121 bp
Protein Name (eCommerce)
Transcription factor 12
RefSeq ID
NM_003205
RefSeq Synonyms
NM_207040, NM_207038, NM_207037, NM_207036, NM_003205, NM_001322165, NM_001322164, NM_001322162, NM_001322161, NM_001322159, NM_001322158, NM_001322157, NM_001322156, NM_001322154, NM_001322152, NM_001322151, NM_001306220, NM_001306219, BC050556,
Research Areas
Immunology,Neurobiology,Neurodevelopment,Neurogenesis,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,developmental_biology,immunology,neurobiology,transcription_translation
Species
human
Target Sentence
TCF12 (transcription factor 12), also known as HeLa E-box binding protein (HEB), is basic helix-loop-helix (bHLH) transcription factor that recognizes consensus E-box binding sites and is found to be important for T-cell development and cell differentiation. TCF12 can interact with the immunoglobulin enhancer binding proteins E12 and ITF2 as hetero-oligomers to modulate their DNA binding activity.
UniGene ID
Hs.511504
UniProt ID (eCommerce)
Q99081

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.