human TAF4 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human TAF4.
shADV-224923
Ad-h-TAF4-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human TAF4 (TATA-box binding protein associated factor 4). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
TAF2C; TAF2C1; TAF4A; TAFII130; TAFII135
Description (Vector)
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that has been shown to potentiate transcriptional activation by retinoic acid, thyroid hormone and vitamin D3 receptors. In addition, this subunit interacts with the transcription factor CREB, which has a glutamine-rich activation domain, and binds to other proteins containing glutamine-rich regions. Aberrant binding to this subunit by proteins with expanded polyglutamine regions has been suggested as one of the pathogenetic mechanisms underlying a group of neurodegenerative disorders referred to as polyglutamine diseases.
Gene ID
6874
Gene Name (Vector)
TATA-box binding protein associated factor 4
Gene Symbol
TAF4
HGNC ID
HGNC:11537
ORF Size (aa)
3258
ORF Size (bp)
3258 bp
RefSeq ID
NM_003185
RefSeq Synonyms
NM_003185, BC167776,
Species
human
UniGene ID
Hs.18857
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.