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human TAF2 shRNA silencing Adenovirus

Name 
Ad-h-TAF2-shRNA
Cat No 
shADV-224921
Availability
Immediate
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human TAF2.

shADV-224921
Ad-h-TAF2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human TAF2 (TATA-box binding protein associated factor 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
150 kDa cofactor of initiator function; CIF150; cofactor of initiator function, 150kD subunit; MRT40; RNA polymerase II TBP-associated factor subunit B; TAF(II)150; TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa; TAF2B; TAFII150; TAFII-150; TATA box binding protein (TBP)-associated factor, RNA polymerase II, B, 150kD; TBP-associated factor 150 kDa; transcription initiation factor TFIID 150 kDa subunit; transcription initiation factor TFIID subunit 2
Description (eCommerce)
TAF2 is a component of the multi-subunit TFIID transcription factor. The TFIID complex is important for coordinating the pre-initiation complex and transcription by RNA Pol II. The complex contains the TFIID protein, TATA binding protein (TBP) and multiple TBP-associated factors (TAFs). TAF2 has been shown to play an important role in gene expression required for progression through the cell cycle.
Description (Vector)
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that is stably associated with the TFIID complex. It contributes to interactions at and downstream of the transcription initiation site, interactions that help determine transcription complex response to activators.
Gene ID
6873
Gene Name (eCommerce)
TATA-box binding protein associated factor 2
Gene Name (Vector)
TATA-box binding protein associated factor 2
Gene Symbol
TAF2
HGNC ID
HGNC:11536
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3597
ORF Size (bp)
3597 bp
Protein Name (eCommerce)
Transcription initiation factor TFIID subunit 2
RefSeq ID
NM_003184
RefSeq Synonyms
NM_003184, BC146379,
Research Areas
Cell Cycle,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,transcription_translation
Species
human
Target Sentence
TAF2 is a component of the multi-subunit TFIID transcription factor. The TFIID complex is important for coordinating the pre-initiation complex and transcription by RNA Pol II. The complex contains the TFIID protein, TATA binding protein (TBP) and multiple TBP-associated factors (TAFs). TAF2 has been shown to play an important role in gene expression required for progression through the cell cycle.
UniGene ID
Hs.122752
UniProt ID (eCommerce)
Q6P1X5

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.