human TAF1C shRNA silencing Adenovirus

Name 
Ad-h-TAF1C-shRNA
Cat No 
shADV-224918
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human TAF1C.

shADV-224918
Ad-h-TAF1C-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human TAF1C (TATA-box binding protein associated factor, RNA polymerase I subunit C). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
50
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
MGC:39976; RNA polymerase I-specific TBP-associated factor 110 kDa; SL1; SL1, 110kD subunit; TAFI110; TAFI95; TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kD; TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa; TATA box-binding protein-associated factor 1C; TATA box-binding protein-associated factor RNA polymerase I subunit C; TATA-box binding protein associated factor, RNA polymerase I, C; TBP-associated factor 1C; transcription factor SL1; transcription initiation factor SL1/TIF-IB subunit C
Description (eCommerce)
TATA box-binding protein-associated factor RNA polymerase I subunit C (TAF1C) is a component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q15572].
Description (Vector)
Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the largest SL1-specific TAF. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
Gene ID
9013
Gene Name (eCommerce)
TATA-box binding protein associated factor, RNA polymerase I subunit C
Gene Name (Vector)
TATA-box binding protein associated factor, RNA polymerase I subunit C
Gene Symbol
TAF1C
HGNC ID
HGNC:11534
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2328
ORF Size (bp)
2328 bp
Protein Name (eCommerce)
TATA box-binding protein-associated factor RNA polymerase I subunit C
RefSeq ID
NM_005679
RefSeq Synonyms
NM_139353, NM_005679, NM_001243160, NM_001243159, NM_001243158, NM_001243157, NM_001243156, BC028131,
Research Areas
Epigenetic Regulation of Gene Expression,Gene Expression,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,genetics,transcription_translation
Species
human
Target Sentence
TATA box-binding protein-associated factor RNA polymerase I subunit C (TAF1C) is a component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q15572].
UniGene ID
Hs.153022
UniProt ID (eCommerce)
Q15572

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.