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human SUPT6H shRNA silencing Adenovirus

Name 
Ad-h-SUPT6H-shRNA
Cat No 
shADV-224752
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human SUPT6H.

shADV-224752
Ad-h-SUPT6H-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human SUPT6H (SPT6 homolog, histone chaperone). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
emb-5; histone chaperone suppressor of Ty6; hSPT6; SPT6; SPT6H; suppressor of Ty 6 homolog; tat-cotransactivator 2 protein; tat-CT2 protein; transcription elongation factor SPT6
Description (eCommerce)
Transcription elongation is one step in the multistage process of transcription that involves the polymerization of nucleoside monophosphates into a ribonucleotide transcript catalyzed by the multisubunit complex RNA Pol II. Transcriptional regulation involves positive factors that promote sufficient elongation rates and processivity as well as negative elongation factors that repress transcription elongation. SUPT6H is hypothesized to play a role in enhancing the rate of transcription elongation in association with RNA Pol II by mobilizing histones and modulating chromatin structure.
Gene ID
6830
Gene Name (eCommerce)
SPT6 homolog, histone chaperone
Gene Name (Vector)
SPT6 homolog, histone chaperone
Gene Symbol
SUPT6H
HGNC ID
HGNC:11470
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
5181
ORF Size (bp)
5181 bp
Protein Name (eCommerce)
Transcription elongation factor SPT6
RefSeq ID
NM_003170
RefSeq Synonyms
NM_003170, NM_001320755, BC150268, BC136524, BC136522,
Research Areas
Chromatin Remodeling,Host-Virus Interactions,mRNA Processing,mRNA Splicing,mRNA transport,RNA Binding,RNA Processing,RNA Transport,Signal Transduction,Transcription Factor/Regulator
Research Areas (Faceted)
signal_transduction,cell_biology,transcription_translation,infectious_disease,genetics,transcription_translation,cell_biology,genetics
Species
human
Target Sentence
Transcription elongation is one step in the multistage process of transcription that involves the polymerization of nucleoside monophosphates into a ribonucleotide transcript catalyzed by the multisubunit complex RNA Pol II. Transcriptional regulation involves positive factors that promote sufficient elongation rates and processivity as well as negative elongation factors that repress transcription elongation. SUPT6H is hypothesized to play a role in enhancing the rate of transcription elongation in association with RNA Pol II by mobilizing histones and modulating chromatin structure.
UniGene ID
Hs.250429
UniProt ID (eCommerce)
Q7KZ85

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.