human STMN1 shRNA silencing Adenovirus

Name 
Ad-h-STMN1-shRNA
Cat No 
shADV-224607
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human STMN1.

shADV-224607
Ad-h-STMN1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human STMN1 (stathmin 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
C1orf215; Lag; LAP18; leukemia-associated phosphoprotein p18; metablastin; oncoprotein 18; OP18; phosphoprotein 19; phosphoprotein p19; PP17; PP19; PR22; prosolin; Protein Pr22; SMN; stathmin; stathmin 1/oncoprotein 18; testicular tissue protein Li 189; transmembrane protein C1orf215
Description (eCommerce)
Stathmin is involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Stathmin is also involved in the control of the learned and innate fear (By similarity) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P16949].
Description (Vector)
STMN1 belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
3925
Gene Name (eCommerce)
stathmin 1
Gene Name (Vector)
stathmin 1
Gene Symbol
STMN1
HGNC ID
HGNC:6510
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
621
Protein Name (eCommerce)
Stathmin
RefSeq ID
NM_005563
RefSeq Synonyms
NM_203401, NM_203399, NM_005563, NM_001145454, BC114502, BC114443, BC082228, BC014353,
Research Areas
Axonogenesis,Breast Cancer,Cancer,Cell Cycle,Cytoskeleton,EGFR Signaling,Host-Virus Interactions,MAPK Signaling,MicroRNAs in Cancer,Neurobiology,Neurodevelopment,Neurogenesis,Response to Virus,Signal Transduction
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,developmental_biology,genetics,immunology,infectious_disease,neurobiology,signal_transduction
Species
human
Target Sentence
Stathmin is involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Stathmin is also involved in the control of the learned and innate fear (By similarity) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P16949].
UniGene ID
Hs.209983
UniProt ID (eCommerce)
P16949

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.