human STAG2 shRNA silencing Adenovirus

Name 
Ad-h-STAG2-shRNA
Cat No 
shADV-224497
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human STAG2.

shADV-224497
Ad-h-STAG2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human STAG2 (stromal antigen 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
bA517O1.1; cohesin subunit SA-2; SA2; SA-2; SCC3 homolog 2; SCC3B; Stromal antigen 2
Description (eCommerce)
SA2 is a component of the multisubunit cohesin complex. Cohesin functions to hold sister chromatids together during meiosis and mitosis and ensure proper segregation of chromosomes. Cohesin must dissociate from sister chromatids during prophase and metaphase so that they can segregate to opposite poles of the cell during anaphase. As part of the cohesin complex, SA2 appears to play a role in cohesin dissociation required for sister chromatid separation. Interestingly, SA2 has been demonstrated to also exhibit transcriptional regulatory activity through an association with NF-kappaB.
Gene ID
10735
Gene Name (eCommerce)
stromal antigen 2
Gene Name (Vector)
stromal antigen 2
Gene Symbol
STAG2
HGNC ID
HGNC:11355
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3696
ORF Size (bp)
3696 bp
Protein Name (eCommerce)
Cohesin subunit SA-2
RefSeq ID
NM_006603
RefSeq Synonyms
NM_006603, NM_001282418, NM_001042751, NM_001042750, NM_001042749, BC001765,
Research Areas
Cell Cycle,Cell Division,Meiosis,PLK1 Signaling,Signal Transduction
Research Areas (Faceted)
cell_biology,cell_cycle,developmental_biology,genetics,signal_transduction
Species
human
Target Sentence
SA2 is a component of the multisubunit cohesin complex. Cohesin functions to hold sister chromatids together during meiosis and mitosis and ensure proper segregation of chromosomes. Cohesin must dissociate from sister chromatids during prophase and metaphase so that they can segregate to opposite poles of the cell during anaphase. As part of the cohesin complex, SA2 appears to play a role in cohesin dissociation required for sister chromatid separation. Interestingly, SA2 has been demonstrated to also exhibit transcriptional regulatory activity through an association with NF-kappaB.
UniGene ID
Hs.624663
UniProt ID (eCommerce)
Q8N3U4

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.