human SOX6 shRNA silencing Adenovirus

Name 
Ad-h-SOX6-shRNA
Cat No 
shADV-224030
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human SOX6.

shADV-224030
Ad-h-SOX6-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human SOX6 (SRY-box 6). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
86
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
HSSOX6; SOXD; SRY (sex determining region Y)-box 6; SRY-box containing gene 6; transcription factor SOX-6
Description (eCommerce)
SRY (Sex determining region Y)- box 6 (SOX6) is a member of the D subfamily of sex determining region y-related transcription factors that are characterized by a conserved DNA-binding domain termed the high mobility group box and by their ability to bind the minor groove of DNA. SOX6 is a transcriptional activator that is required for normal development of the central nervous system, chondrogenesis and maintenance of cardiac and skeletal muscle cells. SOX6 interacts with other family members to cooperatively activate gene expression [taken from NCBI Entrez Gene (Gene ID: 55553)].
Description (Vector)
SOX6 encodes a member of the D subfamily of sex determining region y-related transcription factors that are characterized by a conserved DNA-binding domain termed the high mobility group box and by their ability to bind the minor groove of DNA. The encoded protein is a transcriptional activator that is required for normal development of the central nervous system, chondrogenesis and maintenance of cardiac and skeletal muscle cells. The encoded protein interacts with other family members to cooperatively activate gene expression. Alternative splicing results in multiple transcript variants.
Gene ID
55553
Gene Name (eCommerce)
SRY-box 6
Gene Name (Vector)
SRY-box 6
Gene Symbol
SOX6
HGNC ID
HGNC:16421
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2487
ORF Size (bp)
2487 bp
Protein Name (eCommerce)
Transcription factor SOX-6
RefSeq ID
NM_033326
RefSeq Synonyms
NM_033326, NM_017508, NM_001145819, NM_001145811, BC047064,
Research Areas
Cardiac Development,Cardiology,Cardiovascular,Transcription Factor/Regulator
Research Areas (Faceted)
cardiovascular,cell_biology,developmental_biology,transcription_translation
Species
human
Target Sentence
SRY (Sex determining region Y)- box 6 (SOX6) is a member of the D subfamily of sex determining region y-related transcription factors that are characterized by a conserved DNA-binding domain termed the high mobility group box and by their ability to bind the minor groove of DNA. SOX6 is a transcriptional activator that is required for normal development of the central nervous system, chondrogenesis and maintenance of cardiac and skeletal muscle cells. SOX6 interacts with other family members to cooperatively activate gene expression [taken from NCBI Entrez Gene (Gene ID: 55553)].
UniGene ID
Hs.368226
UniProt ID (eCommerce)
P35712

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.