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human SNX15 shRNA silencing Adenovirus

Name 
Ad-h-SNX15-shRNA
Cat No 
shADV-223922
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human SNX15.

shADV-223922
Ad-h-SNX15-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human SNX15 (sorting nexin 15). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
clone iota unknown protein; HSAF001435; sorting nexin-15
Description (eCommerce)
Sorting nexin-15 (SNX15) may be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9NRS6].
Description (Vector)
SNX15 encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Overexpression of this gene results in a decrease in the processing of insulin and hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the mislocalization of furin, the endoprotease responsible for cleavage of insulin and hepatocyte growth factor receptors. This protein is involved in endosomal trafficking from the plasma membrane to recycling endosomes or the trans-Golgi network. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ADP-ribosylation factor-like 2 (ARL2) gene.
Gene ID
29907
Gene Name (eCommerce)
sorting nexin 15
Gene Name (Vector)
sorting nexin 15
Gene Symbol
SNX15
HGNC ID
HGNC:14978
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1029
Protein Name (eCommerce)
Sorting nexin-15
RefSeq ID
NM_013306
RefSeq Synonyms
NM_147777, NM_013306, BC014520, BC012767, BC009897,
Research Areas
Immunology
Research Areas (Faceted)
immunology
Species
human
Target Sentence
Sorting nexin-15 (SNX15) may be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9NRS6].
UniGene ID
Hs.80132
UniProt ID (eCommerce)
Q9NRS6

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.