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human SNUPN shRNA silencing Adenovirus

Name 
Ad-h-SNUPN-shRNA
Cat No 
shADV-223909
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human SNUPN.

shADV-223909
Ad-h-SNUPN-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human SNUPN (snurportin 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
KPNBL; RNA U transporter 1; RNUT1; Snurportin1; snurportin-1
Description (eCommerce)
Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5, is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5'-2,2,7-terminal trimethylguanosine (m3G) cap structure of the U snRNA and the Sm core domain. Snurportin-1 (SNUPN) interacts specifically with m3G-cap and functions as an snRNP-specific nuclear import receptor [taken from NCBI Entrez Gene (Gene ID: 10073)].
Description (Vector)
The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5, is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5'-2,2,7-terminal trimethylguanosine (m3G) cap structure of the U snRNA and the Sm core domain. The protein encoded by this gene interacts specifically with m3G-cap and functions as an snRNP-specific nuclear import receptor. Alternatively spliced transcript variants encoding the same protein have been identified for this gene.
Gene ID
10073
Gene Name (eCommerce)
snurportin 1
Gene Name (Vector)
snurportin 1
Gene Symbol
SNUPN
HGNC ID
HGNC:14245
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1083
Protein Name (eCommerce)
Snurportin-1
RefSeq ID
NM_005701
RefSeq Synonyms
NM_005701, NM_001042588, NM_001042581, BC004203,
Research Areas
Gene Expression,RNA Binding,RNA Processing,RNA Transport
Research Areas (Faceted)
genetics,transcription_translation,cell_biology
Species
human
Target Sentence
Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5, is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5'-2,2,7-terminal trimethylguanosine (m3G) cap structure of the U snRNA and the Sm core domain. Snurportin-1 (SNUPN) interacts specifically with m3G-cap and functions as an snRNP-specific nuclear import receptor [taken from NCBI Entrez Gene (Gene ID: 10073)].
UniGene ID
Hs.21577
UniProt ID (eCommerce)
O95149

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.