human SMOX shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human SMOX.
shADV-223766
Ad-h-SMOX-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human SMOX (spermine oxidase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
C20orf16; PAO; PAO-1; PAO1; PAOH; PAOH1; SMO
Description (Vector)
Polyamines are ubiquitous polycationic alkylamines which include spermine, spermidine, putrescine, and agmatine. These molecules participate in a broad range of cellular functions which include cell cycle modulation, scavenging reactive oxygen species, and the control of gene expression. These molecules also play important roles in neurotransmission through their regulation of cell-surface receptor activity, involvement in intracellular signalling pathways, and their putative roles as neurotransmitters. This gene encodes an FAD-containing enzyme that catalyzes the oxidation of spermine to spermadine and secondarily produces hydrogen peroxide. Multiple transcript variants encoding different isoenzymes have been identified for this gene, some of which have failed to demonstrate significant oxidase activity on natural polyamine substrates. The characterized isoenzymes have distinctive biochemical characteristics and substrate specificities, suggesting the existence of additional levels of complexity in polyamine catabolism.
Gene ID
54498
Gene Name (Vector)
spermine oxidase
Gene Symbol
SMOX
HGNC ID
HGNC:15862
ORF Size (aa)
1509
ORF Size (bp)
1509 bp
RefSeq ID
NM_175842
RefSeq Synonyms
NM_175842, NM_175841, NM_175840, NM_175839, NM_001270691, BC000669,
Species
human
UniGene ID
Hs.433337
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.