human SMARCA4 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human SMARCA4.
shADV-223712
Ad-h-SMARCA4-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human SMARCA4 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ATP-dependent helicase SMARCA4; BAF190; BAF190A; brahma protein-like 1; BRG1; BRG1-associated factor 190A; BRM/SWI2-related gene 1; CSS4; global transcription activator homologous sequence; homeotic gene regulator; hSNF2b; mitotic growth and transcription activator; MRD16; nuclear protein GRB1; protein brahma homolog 1; protein BRG-1; RTPS2; SNF2; SNF2-beta; SNF2L4; SNF2LB; SNF2-like 4; sucrose nonfermenting-like 4; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4; SWI2; transcription activator BRG1
Description (eCommerce)
The SWI/SNF-related, matrix-associated, actin-dependent regulators of chromatin (SMARC), also called BRG1-associated factors (BAFs), have been identified as components of the human SWI/SNF-like chromatin-remodeling protein complexes. BRG1/SMARCA4 is an ATPase subunit of the SWI/SNF-A chromatin remodeling complex (BAF complex). In BAF complexes, BRG1/SMARCA4 has been shown to interact with BRCA1.
Description (Vector)
SMARCA4 is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
6597
Gene Name (eCommerce)
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
Gene Name (Vector)
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
Gene Symbol
SMARCA4
HGNC ID
HGNC:11100
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
5046
ORF Size (bp)
5046 bp
Protein Name (eCommerce)
Transcription activator BRG1
RefSeq ID
NM_003072
RefSeq Synonyms
NM_003072, NM_001128849, NM_001128848, NM_001128847, NM_001128846, NM_001128845, NM_001128844, BC151849, BC150298, BC136644,
Research Areas
Breast Cancer,Cancer,Cell Cycle,Chromatin Remodeling,Helicase Activity,Histone Modification,Host-Virus Interactions,Neurobiology,Neurodevelopment,Neurogenesis,Nuclear Receptor Coactivators,Prostate Cancer,Signal Transduction,TGF-beta Signaling,TNF Signaling,Transcription Factor/Regulator,Wnt Signaling
Research Areas (Faceted)
cancer,signal_transduction,cell_biology,cell_cycle,transcription_translation,genetics,infectious_disease,neurobiology,developmental_biology,cell_biology,signal_transduction,immunology,genetics,transcription_translation,developmental_biology
Species
human
Target Sentence
The SWI/SNF-related, matrix-associated, actin-dependent regulators of chromatin (SMARC), also called BRG1-associated factors (BAFs), have been identified as components of the human SWI/SNF-like chromatin-remodeling protein complexes. BRG1/SMARCA4 is an ATPase subunit of the SWI/SNF-A chromatin remodeling complex (BAF complex). In BAF complexes, BRG1/SMARCA4 has been shown to interact with BRCA1.
UniGene ID
Hs.327527
UniProt ID (eCommerce)
P51532
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.