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human SHARPIN shRNA silencing Adenovirus

Name 
Ad-h-SHARPIN-shRNA
Cat No 
shADV-222924
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human SHARPIN.

shADV-222924
Ad-h-SHARPIN-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human SHARPIN (SHANK associated RH domain interactor). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
hSIPL1; shank-associated RH domain-interacting protein; shank-interacting protein-like 1; sharpin; SIPL1
Description (eCommerce)
Sharpin (Shank-associated RH domain-interacting protein) is a component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9H0F6].
Gene ID
81858
Gene Name (eCommerce)
SHANK associated RH domain interactor
Gene Name (Vector)
SHANK associated RH domain interactor
Gene Symbol
SHARPIN
HGNC ID
HGNC:25321
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1164
ORF Size (bp)
1164 bp
Protein Name (eCommerce)
Sharpin
RefSeq ID
NM_030974
RefSeq Synonyms
NM_030974, BC034028, BC025244,
Research Areas
Apoptosis,Brain Development,Cancer,CD40 Signaling,Immunology,Neurobiology,Neurodevelopment,NF-kB Signaling,Signal Transduction,Synapse,Ubiquitination,Zinc-finger
Research Areas (Faceted)
cancer,cell_biology,developmental_biology,immunology,neurobiology,signal_transduction
Species
human
Target Sentence
Sharpin (Shank-associated RH domain-interacting protein) is a component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9H0F6].
UniGene ID
Hs.529755
UniProt ID (eCommerce)
Q9H0F6

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.