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human SHANK2 shRNA silencing Adenovirus

Name 
Ad-h-SHANK2-shRNA
Cat No 
shADV-222922
Availability
Immediate
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human SHANK2.

shADV-222922
Ad-h-SHANK2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human SHANK2 (SH3 and multiple ankyrin repeat domains 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
AUTS17; CORTBP1; CTTNBP1; ProSAP1; SHANK; SPANK-3
Description (Vector)
SHANK2 encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density (PSD). Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, an SH3 domain, a PSD-95/Dlg/ZO-1 domain, a sterile alpha motif domain, and a proline-rich region. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain. Two alternative splice variants, encoding distinct isoforms, are reported. Additional splice variants exist but their full-length nature has not been determined.
Gene ID
22941
Gene Name (Vector)
SH3 and multiple ankyrin repeat domains 2
Gene Symbol
SHANK2
HGNC ID
HGNC:14295
ORF Size (aa)
3765
ORF Size (bp)
3765 bp
RefSeq ID
NM_012309
RefSeq Synonyms
NM_133266, NM_012309, BC168372,
Species
human
UniGene ID
Hs.268726

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.