human LZTFL1 Over-expression AAV

Name 
AAV-h-LZTFL1
Cat No 
AAV-214754
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human LZTFL1.

AAV-214754
AAV-h-LZTFL1

Ready-to-use AAV expressing Human LZTFL1 (leucine zipper transcription factor like 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
BBS17; leucine zipper transcription factor-like protein 1
Description (eCommerce)
LZTFL1 is a ubiquitously expressed protein that localizes to the cytoplasm. This protein interacts with Bardet-Biedl Syndrome (BBS) proteins and, through its interaction with BBS protein complexes, regulates protein trafficking to the ciliary membrane. Nonsense mutations in its gene cause a form of Bardet-Biedl Syndrome; a ciliopathy characterized in part by polydactyly, obesity, cognitive impairment, hypogonadism, and kidney failure. This protein may also function as a tumor suppressor; possibly by interacting with E-cadherin and the actin cytoskeleton and thereby regulating the transition of epithelial cells to mesenchymal cells. [provided by RefSeq, Feb 2013] [taken from NCBI Entrez Gene (Gene ID: 54585)].
Gene ID
54585
Gene Name (eCommerce)
leucine zipper transcription factor like 1
Gene Name (Vector)
leucine zipper transcription factor like 1
Gene Symbol
LZTFL1
HGNC ID
HGNC:6741
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
900
ORF Size (bp)
900 bp
Protein Name (eCommerce)
Leucine zipper transcription factor-like protein 1
RefSeq ID
NM_020347
RefSeq Synonyms
NM_020347, NM_001276379, NM_001276378, BC042483, BC025988,
Research Areas
Cell Biology
Research Areas (Faceted)
cell_biology
Species
human
Target Sentence
LZTFL1 is a ubiquitously expressed protein that localizes to the cytoplasm. This protein interacts with Bardet-Biedl Syndrome (BBS) proteins and, through its interaction with BBS protein complexes, regulates protein trafficking to the ciliary membrane. Nonsense mutations in its gene cause a form of Bardet-Biedl Syndrome; a ciliopathy characterized in part by polydactyly, obesity, cognitive impairment, hypogonadism, and kidney failure. This protein may also function as a tumor suppressor; possibly by interacting with E-cadherin and the actin cytoskeleton and thereby regulating the transition of epithelial cells to mesenchymal cells. [provided by RefSeq, Feb 2013] [taken from NCBI Entrez Gene (Gene ID: 54585)].
UniGene ID
Hs.30824
UniProt ID (eCommerce)
Q9NQ48

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.