human SFRS1 shRNA silencing Adenovirus

Name 
Ad-h-SFRS1-shRNA
Cat No 
shADV-222786
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human SRSF1.

shADV-222786
Ad-h-SFRS1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human SRSF1 (serine and arginine rich splicing factor 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
alternative-splicing factor 1; ASF; ASF-1; pre-mRNA-splicing factor SF2, P33 subunit; serine/arginine-rich splicing factor 1; SF2; SF2p33; SFRS1; splicing factor 2; Splicing factor, arginine/serine-rich 1; splicing factor, arginine/serine-rich, 30-KD, A; SR splicing factor 1; SRp30a
Description (eCommerce)
Alternative splicing factor (ASF) is a member of the serine and arginine-rich family of proteins (SR proteins) which function as regulators of pre-mRNA splicing. ASF is a multifunctional RNA binding protein involved in pre-mRNA splicing, mRNA export, and mRNA translation.
Description (Vector)
SRSF1 encodes a member of the arginine/serine-rich splicing factor protein family, and functions in both constitutive and alternative pre-mRNA splicing. The protein binds to pre-mRNA transcripts and components of the spliceosome, and can either activate or repress splicing depending on the location of the pre-mRNA binding site. The protein's ability to activate splicing is regulated by phosphorylation and interactions with other splicing factor associated proteins. Multiple transcript variants encoding different isoforms have been found for this gene. In addition, a pseudogene of this gene has been found on chromosome 13.
Gene ID
6426
Gene Name (eCommerce)
serine and arginine rich splicing factor 1
Gene Name (Vector)
serine and arginine rich splicing factor 1
Gene Symbol
SRSF1
HGNC ID
HGNC:10780
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
606
Protein Name (eCommerce)
Serine/arginine-rich splicing factor 1
RefSeq ID
NM_006924
RefSeq Synonyms
NM_006924, NM_001078166, BC033785, BC010264,
Research Areas
Cardiology,Cardiovascular,Gene Expression,Host-Virus Interactions,mRNA Processing,mRNA Splicing,mRNA Transport,RNA Binding,RNA Processing,RNA Transport,Spliceosome
Research Areas (Faceted)
cardiovascular,genetics,transcription_translation,infectious_disease,cell_biology,genetics,transcription_translation,cell_biology
Species
human
Target Sentence
Alternative splicing factor (ASF) is a member of the serine and arginine-rich family of proteins (SR proteins) which function as regulators of pre-mRNA splicing. ASF is a multifunctional RNA binding protein involved in pre-mRNA splicing, mRNA export, and mRNA translation.
UniGene ID
Hs.68714
UniProt ID (eCommerce)
Q07955

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.