human SEPT7 shRNA silencing Adenovirus

Name 
Ad-h-SEPT7-shRNA
Cat No 
shADV-222613
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human SEPT7.

shADV-222613
Ad-h-SEPT7-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human SEPT7 (septin 7). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
CDC10; CDC10 (cell division cycle 10, S. cerevisiae, homolog); CDC10 protein homolog; CDC3; NBLA02942; SEPT7A; septin 7 variant 4; septin-7
Description (eCommerce)
Septin 7 is a filament-forming cytoskeletal GTPase. Septin 7 is required for normal organization of the actin cytoskeleton and progress through mitosis. Septin 7 is involved in cytokinesis and is required for normal association of CENPE with the kinetochore. It also plays a role in ciliogenesis and collective cell movement [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q16181].
Description (Vector)
7-Sep encodes a protein that is highly similar to the CDC10 protein of Saccharomyces cerevisiae. The protein also shares similarity with Diff 6 of Drosophila and with H5 of mouse. Each of these similar proteins, including the yeast CDC10, contains a GTP-binding motif. The yeast CDC10 protein is a structural component of the 10 nm filament which lies inside the cytoplasmic membrane and is essential for cytokinesis. This human protein functions in gliomagenesis and in the suppression of glioma cell growth, and it is required for the association of centromere-associated protein E with the kinetochore. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified on chromosomes 5, 7, 9, 10, 11, 14, 17 and 19.
Gene ID
989
Gene Name (eCommerce)
septin 7
Gene Name (Vector)
septin 7
Gene Symbol
7-Sep
HGNC ID
HGNC:1717
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1254
ORF Size (bp)
1254 bp
Protein Name (eCommerce)
Septin-7
RefSeq ID
NM_001788
RefSeq Synonyms
NM_001788, NM_001242956, NM_001011553, BC093642, BC093640, BC067264, BC025987,
Research Areas
Cell Cycle,Cell Division,Cytoskeleton
Research Areas (Faceted)
cell_biology,cell_cycle,genetics
Species
human
Target Sentence
Septin 7 is a filament-forming cytoskeletal GTPase. Septin 7 is required for normal organization of the actin cytoskeleton and progress through mitosis. Septin 7 is involved in cytokinesis and is required for normal association of CENPE with the kinetochore. It also plays a role in ciliogenesis and collective cell movement [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q16181].
UniGene ID
Hs.642540
UniProt ID (eCommerce)
Q16181

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.