human SENP7 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human SENP7.
shADV-222578
Ad-h-SENP7-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human SENP7 (SUMO1/sentrin specific peptidase 7). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
sentrin/SUMO-specific protease SENP7; sentrin-specific protease 7; SUMO1/sentrin specific peptidase 7; SUMO-1-specific protease 2
Description (eCommerce)
Sentrin-specific protease 7 (SENP7) is a sumo protease that deconjugates SUMO2 and SUMO3 from targeted proteins, but does not deconjugate SUMO1. SENP7 catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains and has very low efficiency in processing full-length SUMO proteins to their mature forms [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q9BQF6].
Description (Vector)
The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for many cellular processes. SUMO-specific proteases, such as SENP7, process SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 (PubMed 18799455)).(supplied by OMIM, Jun 2009)
Gene ID
57337
Gene Name (eCommerce)
SUMO specific peptidase 7
Gene Name (Vector)
SUMO1/sentrin specific peptidase 7
Gene Symbol
SENP7
HGNC ID
HGNC:30402
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3153
ORF Size (bp)
3153 bp
Protein Name (eCommerce)
Sentrin-specific protease 7
RefSeq ID
NM_020654
RefSeq Synonyms
NM_020654, NM_001282804, NM_001282803, NM_001282802, NM_001282801, NM_001077203, BC129988,
Research Areas
Cell Biology,Ubiquitination
Research Areas (Faceted)
cell_biology
Species
human
Target Sentence
Sentrin-specific protease 7 (SENP7) is a sumo protease that deconjugates SUMO2 and SUMO3 from targeted proteins, but does not deconjugate SUMO1. SENP7 catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains and has very low efficiency in processing full-length SUMO proteins to their mature forms [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q9BQF6].
UniGene ID
Hs.529551
UniProt ID (eCommerce)
Q9BQF6
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.