human S100B shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human S100B.
shADV-222182
Ad-h-S100B-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human S100B (S100 calcium binding protein B). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
NEF; S100; S100-B; S100beta
Description (Vector)
S100B is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes.
Gene ID
6285
Gene Name (Vector)
S100 calcium binding protein B
Gene Symbol
S100B
HGNC ID
HGNC:10500
ORF Size (aa)
279
RefSeq ID
NM_006272
RefSeq Synonyms
NM_006272, BC001766,
Species
human
UniGene ID
Hs.422181
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.