human RPS6KA5 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human RPS6KA5.
shADV-221939
Ad-h-RPS6KA5-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human RPS6KA5 (ribosomal protein S6 kinase A5). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
90 kDa ribosomal protein S6 kinase 5; MSK1; MSPK1; nuclear mitogen- and stress-activated protein kinase 1; ribosomal protein S6 kinase alpha-5; ribosomal protein S6 kinase, 90kDa, polypeptide 5; RLPK; RSKL; RSK-like protein kinase; S6K-alpha-5
Description (eCommerce)
MSK1 is a serine/threonine kinase required for the mitogen or stress-induced phosphorylation of the transcription factors CREB (cAMP response element-binding protein) and ATF1 (activating transcription factor-1). MSK1 Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. MSK1 also phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and epidemal growth-factor (EGF), which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O75582].
Gene ID
9252
Gene Name (eCommerce)
ribosomal protein S6 kinase A5
Gene Name (Vector)
ribosomal protein S6 kinase A5
Gene Symbol
RPS6KA5
HGNC ID
HGNC:10434
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1650
ORF Size (bp)
1650 bp
Protein Name (eCommerce)
Ribosomal protein S6 kinase alpha-5
RefSeq ID
NM_004755
RefSeq Synonyms
NM_182398, NM_004755, NM_001322238, NM_001322237, NM_001322236, NM_001322235, NM_001322234, NM_001322233, NM_001322232, NM_001322231, NM_001322230, NM_001322229, NM_001322228, NM_001322227, BC017187,
Research Areas
Axon Guidance,BDNF Signaling,Bladder Cancer,Cancer,EGFR Signaling,Histone Modification,IFN Signaling,Immunology,Innate Immunity,Insulin Signaling,Interleukin Signaling,Kinase/Phosphatase,MAPK Signaling,MicroRNAs in Cancer,Neurobiology,NGF Signaling,Signal Transduction,TNF Signaling,Toll-like Receptor Signaling,Transcription Factor/Regulator
Research Areas (Faceted)
cancer,cell_biology,genetics,immunology,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
MSK1 is a serine/threonine kinase required for the mitogen or stress-induced phosphorylation of the transcription factors CREB (cAMP response element-binding protein) and ATF1 (activating transcription factor-1). MSK1 Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. MSK1 also phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and epidemal growth-factor (EGF), which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O75582].
UniGene ID
Hs.510225
UniProt ID (eCommerce)
O75582
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.