human RPL7A shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human RPL7A.
shADV-221742
Ad-h-RPL7A-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human RPL7A (ribosomal protein L7a). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
60S ribosomal protein L7a; L7A; large ribosomal subunit protein eL8; PLA-X polypeptide; SURF3; surfeit 3; surfeit locus protein 3; thyroid hormone receptor uncoupling protein; TRUP
Description (eCommerce)
rpL7a /SURF3 is a component of the 60S ribosomal subunit. Ribosomes are composed of a small 40S subunit and a large 60S subunit that function to catalyze protein synthesis. RpL7a is a member of the L7AE family of ribosomal proteins that has been identified as a protein that interacts with nuclear receptors by interfering with DNA binding and transactivation. The RpL7A gene is included in the surfeit gene cluster and is designated SURF3.
Description (Vector)
Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L7AE family of ribosomal proteins. It can interact with a subclass of nuclear hormone receptors, including thyroid hormone receptor, and inhibit their ability to transactivate by preventing their binding to their DNA response elements. This gene is included in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity. It is co-transcribed with the U24, U36a, U36b, and U36c small nucleolar RNA genes, which are located in its second, fifth, fourth, and sixth introns, respectively. This gene rearranges with the trk proto-oncogene to form the chimeric oncogene trk-2h, which encodes an oncoprotein consisting of the N terminus of ribosomal protein L7a fused to the receptor tyrosine kinase domain of trk. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.
Gene ID
6130
Gene Name (eCommerce)
ribosomal protein L7a
Gene Name (Vector)
ribosomal protein L7a
Gene Symbol
RPL7A
HGNC ID
HGNC:10364
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
801
ORF Size (bp)
801 bp
Protein Name (eCommerce)
60S ribosomal protein L7a
RefSeq ID
NM_000972
RefSeq Synonyms
NM_000972, BC105290, BC073802, BC071901, BC071900, BC023624, BC023594, BC021979, BC005128,
Research Areas
Gene Expression,Host-Virus Interactions,Metabolism/Metabolic Process,RNA Binding,RNA Processing,Translational Control
Research Areas (Faceted)
cell_biology,genetics,infectious_disease,metabolism,transcription_translation
Species
human
Target Sentence
rpL7a /SURF3 is a component of the 60S ribosomal subunit. Ribosomes are composed of a small 40S subunit and a large 60S subunit that function to catalyze protein synthesis. RpL7a is a member of the L7AE family of ribosomal proteins that has been identified as a protein that interacts with nuclear receptors by interfering with DNA binding and transactivation. The RpL7A gene is included in the surfeit gene cluster and is designated SURF3.
UniGene ID
Hs.499839
UniProt ID (eCommerce)
P62424
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.