human RPL23A shRNA silencing Adenovirus

Name
Ad-h-RPL23A-shRNA

Cat No
shADV-221638

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Human RPL23A.

shADV-221638

Ad-h-RPL23A-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human RPL23A (ribosomal protein L23a). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

60S ribosomal protein L23a; L23A; large ribosomal subunit protein uL23; MDA20; melanoma differentiation-associated gene 20

Description (eCommerce)

Ribosomal protein L23a (RPL23A) binds to a specific region on the 26S rRNA (by similarity) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P62750].

Description (Vector)

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L23P family of ribosomal proteins. It is located in the cytoplasm. The protein may be one of the target molecules involved in mediating growth inhibition by interferon. In yeast, the corresponding protein binds to a specific site on the 26S rRNA. This gene is co-transcribed with the U42A, U42B, U101A, and U101B small nucleolar RNA genes, which are located in its third, first, second, and fourth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.

Gene ID

6147

Gene Name (eCommerce)

ribosomal protein L23a

Gene Name (Vector)

ribosomal protein L23a

Gene Symbol

RPL23A

HGNC ID

HGNC:10317

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

471

Protein Name (eCommerce)

60S ribosomal protein L23a

RefSeq ID

NM_000984

RefSeq Synonyms

NM_000984, BC058041, BC014459,

Research Areas

Gene Expression,Host-Virus Interactions,Metabolism/Metabolic Process,RNA Binding,RNA Processing,Translational Control

Research Areas (Faceted)

cell_biology,genetics,infectious_disease,metabolism,transcription_translation

Species

human

Target Sentence

Ribosomal protein L23a (RPL23A) binds to a specific region on the 26S rRNA (by similarity) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P62750].

UniGene ID

Hs.419463

UniProt ID (eCommerce)

P62750

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.