human F11R shRNA silencing Adenovirus

Name 
Ad-h-F11R-shRNA
Cat No 
shADV-221517
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human F11R.

shADV-221517
Ad-h-F11R-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human F11R (F11 receptor). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
CD antigen CD321; CD321; JAM; JAM1; JAM-1; JAMA; JAM-A; JCAM; junctional adhesion molecule 1; junctional adhesion molecule A; KAT; PAM-1; platelet adhesion molecule 1; platelet F11 receptor
Description (eCommerce)
Junctional adhesion molecule A (JAM-A) is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor [taken from NCBI Entrez Gene (Gene ID: 50848)].
Description (Vector)
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established.
Gene ID
50848
Gene Name (eCommerce)
F11 receptor
Gene Name (Vector)
F11 receptor
Gene Symbol
F11R
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
900
Protein Name (eCommerce)
Junctional adhesion molecule A
RefSeq ID
NM_016946
RefSeq Synonyms
NM_016946, BC001533,
Research Areas
Angiogenesis,Cardiovascular,Host-Virus Interactions,Immunology,Signal Transduction,TGF-beta Signaling
Research Areas (Faceted)
cancer,cardiovascular,developmental_biology,immunology,infectious_disease,signal_transduction
Species
human
Target Sentence
Junctional adhesion molecule A (JAM-A) is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor [taken from NCBI Entrez Gene (Gene ID: 50848)].
UniGene ID
Hs.517293
UniProt ID (eCommerce)
Q9Y624

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.