human ROR1 shRNA silencing Adenovirus

Name
Ad-h-ROR1-shRNA

Cat No
shADV-221489

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Human ROR1.

shADV-221489

Ad-h-ROR1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human ROR1 (receptor tyrosine kinase like orphan receptor 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

dJ537F10.1; NTRKR1

Description (Vector)

ROR1 encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. ROR1 is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene ID

4919

Gene Name (Vector)

receptor tyrosine kinase like orphan receptor 1

Gene Symbol

ROR1

HGNC ID

HGNC:10256

ORF Size (aa)

2811

ORF Size (bp)

2811 bp

RefSeq ID

NM_005012

RefSeq Synonyms

NM_005012, NM_001083592, BC172555, BC156511,

Species

human

UniGene ID

Hs.654491

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.