human RNF19A shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human RNF19A.
shADV-221393
Ad-h-RNF19A-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human RNF19A (ring finger protein 19A, RBR E3 ubiquitin protein ligase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Dorfin; double ring-finger protein; E3 ubiquitin-protein ligase RNF19A; p38; protein p38 interacting with transcription factor Sp1; ring finger protein 19; RING finger protein 19A; ring finger protein 19A, E3 ubiquitin protein ligase; ring-IBR-ring domain containing protein Dorfin; RNF19
Description (eCommerce)
Dorfin is an E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Dorfin specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation and to neuronal protection.uniprot.org/uniprot/Q9NV58].
Description (Vector)
RNF19A contains two RING-finger motifs and an IBR (in between RING fingers) motif. This protein is an E3 ubiquitin ligase that is localized in Lewy bodies, a characteristic neuronal inclusion in Parkinson's disease (PD) brains. This protein interacts with UBE2L3/UBCH7 and UBE2E2/UBCH8, but not other ubiquitin-conjugating enzymes. This protein binds and ubiquitylates synphilin 1 (SNCAIP) which is an interacting protein of alpha synuclein in neurons and a major component of Lewy bodies. Alternative splicing results in multiple transcript variants encoding the same protein.
Gene ID
25897
Gene Name (eCommerce)
ring finger protein 19A, RBR E3 ubiquitin protein ligase
Gene Name (Vector)
ring finger protein 19A, RBR E3 ubiquitin protein ligase
Gene Symbol
RNF19A
HGNC ID
HGNC:13432
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2517
ORF Size (bp)
2517 bp
Protein Name (eCommerce)
E3 ubiquitin-protein ligase RNF19A
RefSeq ID
NM_015435
RefSeq Synonyms
NM_183419, NM_015435, NM_001280539, BC093940, BC093938,
Research Areas
Cytoskeleton,Neurobiology,Neurodegeneration,Parkinson's Disease,Parkin-Ubiquitin Proteasomal System,Transcription Factor/Regulator,Ubiquitination,Zinc-finger
Research Areas (Faceted)
cell_biology,neurobiology,transcription_translation
Species
human
Target Sentence
Dorfin is an E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Dorfin specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation and to neuronal protection.uniprot.org/uniprot/Q9NV58].
UniGene ID
Hs.292882
UniProt ID (eCommerce)
Q9NV58
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.