human RNF138 shRNA silencing Adenovirus

Name 
Ad-h-RNF138-shRNA
Cat No 
shADV-221352
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human RNF138.

shADV-221352
Ad-h-RNF138-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human RNF138 (ring finger protein 138). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
E3 ubiquitin-protein ligase RNF138; hNARF; HSD-4; NARF; nemo-like kinase associated ring finger protein; Nemo-like kinase-associated RING finger protein; NLK-associated RING finger protein; RING finger protein 138; ring finger protein 138, E3 ubiquitin protein ligase; RING-type E3 ubiquitin transferase RNF138; STRIN; testicular tissue protein Li 165
Description (eCommerce)
RING-finger protein 138 (RNF138) is an E3 ubiquitin ligase. Together with NLK, RNF138 is involved in the ubiquitination and degradation of TCF/LEF. RNF138 also exhibits auto-ubiquitination activity in combination with UBE2K. RNF138 may act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q8WVD3].
Description (Vector)
RNF138 contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Gene ID
51444
Gene Name (eCommerce)
ring finger protein 138
Gene Name (Vector)
ring finger protein 138
Gene Symbol
RNF138
HGNC ID
HGNC:17765
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
738
Protein Name (eCommerce)
E3 ubiquitin-protein ligase RNF138
RefSeq ID
NM_016271
RefSeq Synonyms
NM_198128, NM_016271, NM_001191324, BC018107,
Research Areas
Antigen Processing and Presentation,Immunology,Signal Transduction,Ubiquitination,Wnt Signaling,Zinc-finger
Research Areas (Faceted)
cell_biology,immunology,signal_transduction
Species
human
Target Sentence
RING-finger protein 138 (RNF138) is an E3 ubiquitin ligase. Together with NLK, RNF138 is involved in the ubiquitination and degradation of TCF/LEF. RNF138 also exhibits auto-ubiquitination activity in combination with UBE2K. RNF138 may act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q8WVD3].
UniGene ID
Hs.302408
UniProt ID (eCommerce)
Q8WVD3

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.