human REXO2 shRNA silencing Adenovirus

Name 
Ad-h-REXO2-shRNA
Cat No 
shADV-221029
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human REXO2.

shADV-221029
Ad-h-REXO2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human REXO2 (RNA exonuclease 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
CGI-114; oligoribonuclease, mitochondrial; REX2; REX2, RNA exonuclease 2 homolog; RFN; RNA exonuclease 2 homolog; SFN; small fragment nuclease
Description (eCommerce)
REXO2 is a 3'-to-5' exoribonuclease specific for small oligoribonucleotides.It is active on small (primarily </=5 nucleotides in length) single-stranded RNA and DNA oligomers. It may have a role in cellular nucleotide recycling [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9Y3B8].
Description (Vector)
REXO2 encodes a 3'-to-5' exonuclease specific for small (primarily 5 nucleotides or less in length) single-stranded RNA and DNA oligomers. This protein may have a role in DNA repair, replication, and recombination, and in RNA processing and degradation. It may also be involved in resistance of human cells to UV-C-induced cell death through its role in the DNA repair process.
Gene ID
25996
Gene Name (eCommerce)
RNA exonuclease 2
Gene Name (Vector)
RNA exonuclease 2
Gene Symbol
REXO2
HGNC ID
HGNC:17851
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
714
Protein Name (eCommerce)
Oligoribonuclease, mitochondrial
RefSeq ID
NM_015523
RefSeq Synonyms
NM_015523, BC143701, BC107887, BC105026, BC105024,
Research Areas
Mitochondrion
Research Areas (Faceted)
cell_biology
Species
human
Target Sentence
REXO2 is a 3'-to-5' exoribonuclease specific for small oligoribonucleotides.It is active on small (primarily </=5 nucleotides in length) single-stranded RNA and DNA oligomers. It may have a role in cellular nucleotide recycling [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9Y3B8].
UniGene ID
Hs.677190
UniProt ID (eCommerce)
Q9Y3B8

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.