human RBM9 shRNA silencing Adenovirus

Name 
Ad-h-RBM9-shRNA
Cat No 
shADV-220892
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human RBFOX2.

shADV-220892
Ad-h-RBM9-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human RBFOX2 (RNA binding protein, fox-1 homolog 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
dJ106I20.3; fox-1 homolog B; fox-1 homologue; FOX2; Fox-2; fxh; hexaribonucleotide-binding protein 2; HNRBP2; HRNBP2; RBM9; repressor of tamoxifen transcriptional activity; RNA binding protein fox-1 homolog 2; RNA binding protein, fox-1 homolog 2; RNA-binding motif protein 9; RNA-binding protein 9; RTA
Description (eCommerce)
FOX2/RBM9 is an RNA binding protein thought to be a key regulator of alternative exon splicing in the nervous system and other cell types. It binds to a conserved UGCAUG element found downstream of many alternatively spliced exons and promotes inclusion of the alternative exon in mature transcripts, and also interacts with the estrogen receptor 1 transcription factor and regulates estrogen receptor 1 transcriptional activity.[RefSeq]
Description (Vector)
RBFOX2 is one of several human genes similar to the C. elegans gene Fox-1. RBFOX2 encodes an RNA binding protein that is thought to be a key regulator of alternative exon splicing in the nervous system and other cell types. The protein binds to a conserved UGCAUG element found downstream of many alternatively spliced exons and promotes inclusion of the alternative exon in mature transcripts. The protein also interacts with the estrogen receptor 1 transcription factor and regulates estrogen receptor 1 transcriptional activity. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
23543
Gene Name (eCommerce)
RNA binding fox-1 homolog 2
Gene Name (Vector)
RNA binding protein, fox-1 homolog 2
Gene Symbol
RBFOX2
HGNC ID
HGNC:9906
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1077
ORF Size (bp)
1077 bp
Protein Name (eCommerce)
RNA binding protein fox-1 homolog 2
RefSeq ID
NM_014309
RefSeq Synonyms
NM_014309, NM_001082579, NM_001082578, NM_001082577, NM_001082576, NM_001031695, BC025281, BC013115,
Research Areas
Estrogen Signaling,mRNA Processing,mRNA Splicing,RNA Binding,RNA Processing,Signal Transduction,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,genetics,signal_transduction,transcription_translation
Species
human
Target Sentence
FOX2/RBM9 is an RNA binding protein thought to be a key regulator of alternative exon splicing in the nervous system and other cell types. It binds to a conserved UGCAUG element found downstream of many alternatively spliced exons and promotes inclusion of the alternative exon in mature transcripts, and also interacts with the estrogen receptor 1 transcription factor and regulates estrogen receptor 1 transcriptional activity.[RefSeq]
UniGene ID
Hs.282998
UniProt ID (eCommerce)
O43251

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.