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human RBM22 shRNA silencing Adenovirus

Name 
Ad-h-RBM22-shRNA
Cat No 
shADV-220856
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human RBM22.

shADV-220856
Ad-h-RBM22-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human RBM22 (RNA binding motif protein 22). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
60
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
Cwc2; fSAP47; functional spliceosome-associated protein 47; pre-mRNA-splicing factor RBM22; RNA-binding motif protein 22; ZC3H16; zinc finger CCCH domain-containing protein 16
Description (eCommerce)
RNA binding motif protein 22 (RBM22) is involved in the first step of pre-mRNA splicing. It binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle. RBM22 is involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic calcium-binding protein PDCD6 to the nucleus upon cellular stress responses [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9NW64].
Description (Vector)
RBM22 encodes an RNA binding protein. The encoded protein may play a role in cell division and may be involved in pre-mRNA splicing. Related pseudogenes exist on chromosomes 6, 7, 9, 13, 16, 18, and X.
Gene ID
55696
Gene Name (eCommerce)
RNA binding motif protein 22
Gene Name (Vector)
RNA binding motif protein 22
Gene Symbol
RBM22
HGNC ID
HGNC:25503
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1263
ORF Size (bp)
1263 bp
Protein Name (eCommerce)
Pre-mRNA-splicing factor RBM22
RefSeq ID
NM_018047
RefSeq Synonyms
NM_018047, BC003402,
Research Areas
Gene Expression,mRNA Processing,mRNA Splicing,RNA Binding,RNA Processing,Spliceosome,Transport,Zinc-finger
Research Areas (Faceted)
genetics,transcription_translation,cell_biology
Species
human
Target Sentence
RNA binding motif protein 22 (RBM22) is involved in the first step of pre-mRNA splicing. It binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle. RBM22 is involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic calcium-binding protein PDCD6 to the nucleus upon cellular stress responses [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9NW64].
UniGene ID
Hs.713564
UniProt ID (eCommerce)
Q9NW64

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.